Germany Jahrgangsstufe 11 Chemistry
Chapters: 3
1. How chemists think and work
How chemists think and work
- Lab Safety and Safe Experiments – Dress for safety (goggles, coat, closed shoes, hair tied). Read labels and hazard pictograms. Heat gently with the mouth of the tube pointing away. Add acid to water, waft smells, never taste. Report every accident at once. Plan experiments step by step, assess the risks first and dispose of waste correctly.
2. Food chemistry
Food chemistry
- Biomolecules – A cell is mostly water, plus four big families of carbon compounds: proteins, carbohydrates, lipids and nucleic acids. Grinding tissue in acid separates small molecules (acid-soluble pool) from big ones – proteins, polysaccharides and nucleic acids (acid-insoluble pool). Proteins are chains of amino acids folded into four levels of structure. Polysaccharides are chains of sugars; lipids are fatty acids on glycerol; nucleic acids are chains of nucleotides. Enzymes are protein catalysts that bind a substrate at the active site, lower the activation energy, and are affected by temperature, pH, substrate level and inhibitors.
3. Pharmacy
Medicines for the digestive system · Painkillers: composition and synthesis
- Ionic Equilibrium: Acids, Bases, Ionisation and pH – Acids and bases can be defined in three ways: Arrhenius (give H⁺ or OH⁻ in water), Brønsted–Lowry (proton donor or acceptor) and Lewis (electron-pair acceptor or donor). Strong acids and bases ionise fully; weak ones ionise only a little and set up an equilibrium with constant Ka or Kb. Water itself ionises: Kw = [H⁺][OH⁻] = 1.0 × 10⁻¹⁴ at 25 °C. pH = −log[H⁺] and pH + pOH = 14. For a weak electrolyte, α ≈ √(K/C), so dilution increases α (Ostwald's dilution law). For a conjugate pair, Ka × Kb = Kw. Salts of weak acids or weak bases react with water (hydrolysis) and give non-neutral solutions.
- Painkillers: How Aspirin Is Made and Checked – Drug molecules are built from functional groups such as -OH, -COOH, ester and amide. Retrosynthesis works backwards from the target. Aspirin is made by acetylating the -OH of salicylic acid with acetic anhydride (an ester forms by addition then elimination, with an acid catalyst). Purity is checked by melting point, an iron(III) chloride test and thin-layer chromatography, where Rf = distance of spot / distance of solvent front.